Hearts of Oak attacker Daniel Afriyie Barnieh and German-based Braydon Manu and Abdul Baba Rahman have made returns to the Black Stars team.
Inform Bechem United forward Augustine Okrah as well as Bristol City attacker Antione Semenyo have been included.
Strasbourg defender Alexander Djiku however misses out from the team.
Ghana will take on Madagascar on Wednesday, June 1 before taking on Central African Republic four days later. With the World Cup around the corner, Otto Addo will lead his charges to a four-nation tournament in Japan as part of preparations towards the FIFA World Cup.
Check out Ghana’s squad below